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Antifungal drug Lotrisone (betamethasone/clotrimazole)

The basic name of Lotrisone is clotrimazole or betamethasone dipropionate. This combination drug is used for the treatment of several fungal skin diseases like athlete’s foor, jock itch and ringworm.

Lotrisone (betamethasone/clotrimazole) cream

Composition of Lotrisone

Clotrimazole is chemically an imidazole with the chemical formula C22H17ClN2 and molecular mass of 344.84 g/mol. Clotrimazole is a white, odorless, crystalline powder which is soluble in ethanol and insoluble in water. Betamethasone dipropionate has an empirical formula C28H37FO7 with a molar mass of 504.59 g/mol.


Lotrisone is used for the topical treatment of inflammatory fungal infections like tinea cruris, tinea corporis and tinea pedis caused by Trichophtyon rubrum ,Trichophyton mentagrophytes, and Epidermophyton floccosum in patients ageing 17 years and above. Lotrisone consists of two medicines. Clotrimazole is an azole antifungal agent which works by stopping the growth of the fungi. Betamethasone is a corticosteroid which works by decreasing the redness, itching and swelling of skin due to infection.

How to use Lotrisone

Hands should be properly washed after the application of the cream on the affected skin. The dosage and duration of the therapy is based on the type of fungal infection. Jock itch or ringworm requires complete 2 weeks to be treated whereas athlete’s foot is usually treated in 4 weeks. The drug should be applied regularly to gain maximum advantages from it.

For the treatment of tinea cruris or tinea corporis:

For the treatment of tinea pedis:

Lotrisone cream is meant only for topical purpose. The administration of this drug should not be intravaginal, oral or ophthalmic.

Side-Effects of Lotrisone

Lotrisone cream may commonly cause dry skin, tingling, burning or stinging effects on the applied skin. Inform your doctor if any of these infrequent but adverse side-effects are observed: skin discoloration/thickening, stretch marks, increased thirst, extreme hair growth, folliculitis or hair bumps, excessive/abnormal tiredness, weight loss, headache, swollen feet/ankles, vision problems, allergic reactions like trouble breathing, rashes, itching or swelling of tongue/face/throat, severe dizziness or increased urination.

Contraindications of Lotrisone

Tell your doctor about your allergies to betamethasone or clotrimazole or any other azole antifungal agents like ketoconazole or corticosteroids such as triamcinolone. Let the doctor know about your past medical conditions, especially of: weak blood circulatory system, problems in immune system.

Pregnancy and Lotrisone

This drug should be administered during pregnancy period only when it is clearly required. The risks and advantages of the medication should be discusses with the doctor. It is not clearly known whether the drug is capable of passing into the human milk when applied on the skin. Similar drugs are excreted into the breast milk when taken orally. Therefore it is important to notify the doctor before breastfeeding.

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