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Principen (ampicillin)

Principen is a type of penicillin antibiotic that is used for treating many infections caused by bacteria. They are found in many forms like oral suspension and injectable solution. There are many side-effects that may result from its usage. Therefore, a doctor should always be consulted before taking this antibiotic medication. Ampicillin is the generic name of this drug and it is sold under other names like amcill, omnipen and even principen. It belongs to the group of drugs known as aminopenicillins. Principen has been approved by the FDA in 1965.

Principen (ampicillin) capsules


The dosage of Principen (ampicillin) can vary depending on the specific condition being treated, the severity of the infection, and the guidance of your healthcare provider. It is important to follow the instructions provided by your doctor or the directions on the prescription label.

For most common bacterial infections, the typical adult dosage of Principen is 250 to 500 mg taken orally every 6 hours. However, the dosage may be adjusted based on the specific infection and the individual's response to treatment.

For pediatric patients, the dosage is usually determined based on their weight. The pediatric dosage of Principen is typically prescribed as a once-daily or divided-dose regimen, with the specific amount determined by the child's weight.

The duration of treatment with Principen will depend on the type and severity of the infection. It is important to complete the full course of treatment as prescribed by your healthcare professional, even if your symptoms improve before the medication is finished. Skipping doses or stopping the medication prematurely can lead to incomplete treatment and a higher risk of the infection recurring.


This drug is a semisynthetic penicillin drug. Ampicillin trihydrate is an anhydrous form of ampicillin. The trihydrate is available when 3 water (H20) molecules are attached to it. The capsules of principen used for oral administration contain the following ingredients:

The inactive ingredients in the oral suspension of Principen are:


Principen is used for the treatment of various types of bacterial infections. This penicillin-type drug helps in preventing the growth of bacteria inside the body. Generic ampicillin can be used for treating meningitis, typhoid fever, bronchitis, pneumonia, and urinary tract infections. Dentists may also prescribe this antibiotic before a dental procedure for ruling out the risk of endocarditis (infection in the lining present in the heart).

This medication can only be used for treating infections caused by bacteria. They are not helpful in case of viral infections (like flu and common cold). Overuse and unnecessary usage of this drug can reduce its effectiveness.

Side effects

There are various side-effects associated with the use of principen that may require medical attention. Some of these side-effects are as follows:

Principen is a type of penicillin antibiotic that is used for treating many infections


If the patient has any of the following conditions, he/she should not be prescribed this medication:

Principen and pregnancy

The FDA had assigned principen to Pregnancy Category B which suggests the drug not being harmful to the fetus in animal studies. But as there are no controlled data on humans, the physician should be informed in advance if the patient is expecting or plans on being pregnant.

Some frequently asked questions about Ampicillin

What is ampicillin?

Ampicillin is an antibiotic medication that belongs to the penicillin class. It is commonly used to treat a variety of bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and certain types of gastrointestinal infections.

How does ampicillin work?

Ampicillin works by inhibiting the growth and spread of bacteria in the body. It does this by interfering with the synthesis of bacterial cell walls, ultimately leading to their destruction.

What conditions can ampicillin treat?

Ampicillin is used to treat bacterial infections caused by susceptible organisms. It is effective against a wide range of bacteria, including Streptococcus, Staphylococcus, Escherichia coli, and Haemophilus influenzae, among others.

How is ampicillin administered?

Ampicillin is typically taken orally in the form of capsules or a suspension. It can be taken with or without food, as directed by your healthcare provider. The specific dosage and duration of treatment will depend on the type and severity of the infection.

Are there any side effects associated with ampicillin?

Like any medication, ampicillin can cause side effects. Common side effects may include nausea, vomiting, diarrhea, stomach pain, rash, and allergic reactions. If you experience severe or persistent side effects, it is important to contact your healthcare provider.

Can ampicillin interact with other medications?

Ampicillin may interact with certain medications, including other antibiotics, oral contraceptives, and anticoagulants. It is important to inform your healthcare provider about all the medications you are currently taking to avoid potential interactions.

Can ampicillin be used during pregnancy or while breastfeeding?

It is important to consult with your healthcare provider before using ampicillin during pregnancy or while breastfeeding. They can evaluate the potential risks and benefits and provide guidance based on your specific situation.

What should I do if I miss a dose of ampicillin?

If you miss a dose, take it as soon as you remember, unless it is close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

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