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Antifungal drug Diflucan (fluconazole)

Diflucan is the brand name for Fluconazole. It is an antifungal medicine. Fluconazole is the first of its name to be present as a new subclass of the synthetic tri-azole anti-fungal agents. Fluconazole is a white colour crystalline solid which is mildly soluble in water

Diflucan (fluconazole) capsules

Mechanism of action (MOA)

Fluconazole impedes the enzyme 14 alpha –demethylase produce by the fungal cytochrome P450. This hinderance prevents the lanosterol conversion to ergosterol and subsequent collection of 14 alpha- methyl sterols. It is also a fungicidal agent mostly for cryptococcus.

Uses of Diflucan

  1. Vaginal yeast infections
  2. Cryptococcal meningitis
  3. Esophageal candidiasis
  4. Oral fungal infection
  5. Urinary tract infection
  6. Pneumonia
  7. Disseminated infections
  8. Peritonitis

Also it helps in treating the infections after chemotherapy and radiation for the bone marrow transplantation and also in AIDS.

Dosage and Administration

The dosage for fluconazole is 150 miligram orally single dose.

  1. For multiple dosage
  2. For oropharyngeal candidiasis
  3. The recommended dose is 250mg started on the first day followed by 100mg once everyday
  4. For esophageal candidiasis
  5. The dose recommended is 200mg followed by 100mg daily. The dose can go up-to 400mg maximum
  6. For systemic candidiasis

Information for the use of Diflucan tablets 50 mg and 100 mg, powder for oral suspension 50 mg/5 ml, injection 100 ml vial.

Doses up-to 400mg can be used.

For cryptococcal meningitis

The recommended dosage is 400mg followed by 200mg once everyday. The doses are medically monitored by doctor.

Intitial therapy for Diflucan can be continued till 10-12 weeks and then only it should be stopped.


Side-Effects of Diflucan

Common side-effects are

Precautions and Warnings

In cases of Liver Dysfunction Fluconazole should be administered with extreme caution as it may cause hepatic toxicity.

Fluconazole should be taken with caution as it has been reported that it causes prolonged QT interval. Q-T interval from the ECG. Also there is risk of cardio toxicity if fluconazole and erythromycin are ever combined.

Please be caution when driving a vehicle as it causes dizzy spells sometimes after taking Fluconazole.

Pregnancy and Breast-Feeding

Reports have been suggested that taking this drug while pregnant or trying to get pregnant is harmful as it will cause miscarriage in a pregnant women. Please consult your doctor for an alternative drug if you are suffering from vulvovaginal yeast infections. You can use topical antifungals during that time as they are mild compared to others.

Also it enters the breast milk so please take caution while using it.

Drug Interaction

Drugs like phenytoin, rifampin, cisapride, oral hypoglycemics, oral contraceptives, rifabutin, tacrolimus , cyclosporine ,short acting benzodiazepines , theophylline , amphotericin B, losartan and prednisolone etc are some of the drugs that while combined with Fluconazole can change the course of action of the drug. Please let your doctor know about the drugs you use before taking them.

Diflucan is the brand name for Fluconazole

Fungi is the most wide spread species of plantae kingdom on earth. It habitats ranger from hundreds of degrees of temperature to the most dehydrated conditions. Due to its versatility and successful survival, the fungi also infect and damage human bodies. Diseases of various organs are invaded by a variety of fungi. Consequently, research has lead to the development of anti-fungi drugs and Diflucan is one of them.

Infections of both, superficial and deep nature are treated by Diflucan effectively. The drug chiefly is a fungi-static i.e. it halts the growth of fungi. The drug acts to inhibit the activity of demethylase enzyme significantly. Fungal demethylase enzyme is responsible for the accommodation of lanosterol and ergosterol in their cellular membranes to complete its structure. When inhibit, the membrane formed is defected and the fungus is prevented from thriving in the human body.

Diflucan is an important treatment-resistant drug that is to be given when all the fungicides have failed to cut fungal growth at the infection site. Candida albicans is a special kind of yeast that infects human organs like skin armpits, mouth, groin, folds of buttocks and also the genital organs in both the sexes. Candidasis can be superficial or of systemic form in more severe cases. Diflucan provides an effective treatment for candidasis and reduced the infection significantly.

Vaginal yeast infection is most susceptible when taking oral pills, irritation by vaginal douches, pregnancy tensions and vaginal sex immediately after anal sex. 75% of the women suffer from yeast infection at some stage of their life.

Patients with chronic fungal or yeast infection are readily curable by the drug. Diflucan is toxic if taken for too long but is counted among its family with less toxicity. Another positive aspect of diflucan over other anti-fungi drug is that it is absorbed systemically in an effective way.

The natural acidity of stomach does not interfere with the absorption of the drug and its subsequent appearance in urine, tears and skin. This is on of the characters that make the drug perfect for the treatment of vaginal infections and skin infections. Orally taken, Diflucan is prescribed with a dosage of 150mg tablets daily for genital infections, 500-600 mg daily for systemic infections and 150-300 mg weekly for skin infections. For immediate treatment of adverse meningitis 800mg potency is advised to be taken daily.

The side effects of the drug include cardiac arrhythmias and toxicity of liver. It appears in the breast milk readily thus unadvisable for lactating women. People showing allergic responses to other azole drugs should also not resort to such drug. Liability to anaphylaxis may also be increased. Adverse drug reactions may include anorexia, fatigue, headache, nausea, diarrhea, constipation, and hepatic failure and torsades de pointes in the rarest conditions.

If you have been using anti-fungal drugs and the infection still persists, Diflucan is potent enough to actively remove even the adverse sort of yeast infections. Diflucan can now be readily availed from our online pharmacy. Our online facilities ensure for our visitors original quality medicine to be availed conveniently in the most affordable way.

Brand names in France

Beagyne, Triflucan.

Brand names in Spain

Citiges, Lavisa, Loitin, Nesporac, Solacap.

Brand names in Italy

Biozolene, Elazor, Flumicon, Lefunzol, Riflax, Winch.

Brand names in Australia

Dizole, Fluzole, Ozole.

Brand names in Mexico

Afungil, Bioxel, Candizol, Difusel, Fectrin, Fharder, Fleridux, Flucoxan, Fludisol, Fluhexal, Flukenol, Flukezol, Fluxes, Fluxicap, Fluzor, Funser, Lanfluzol, Menifar, Neofomiral, Ongicil, Oxifungol, Ranflu, Solarisol, Terplex, Waynazol, Zilrin, Zoldicam, Zonal.

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