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Gyne-Lotrimin (clotrimazole)

It is the brand name for Clotrimazole. It is an antifungal medicine that is used to treat vaginal yeast infections. This product comes in two form tablet or cream. Cream is used to apply on the outer region of the vagina.

Gyne-Lotrimin (clotrimazole) cream

Mechanism Of action (MOA)

Clotrimazole is an anti funfal medicine which kills the fungal cells by inhibiting the permeability of the fungal cell wall. The cell membrane is formed by sterols and ergosterol therefore it binds with phospholipids and blocks the production of ergosterol and sterol. This causes cell death.


This drug is mainly used for treating vaginal yeast infections. This medicine comes in cream and tablet form. It works by inhibiting the growth of yeast and stops the itching and burning. Apply cream on the outside skin of the vagina.


The recommended dosage for Gyne-Lotrimin is as follows:

For Vaginal Cream:

For Vaginal Suppositories:

It is essential to follow the prescribed dosage and directions given by your healthcare provider. If you have any questions or concerns, consult with your doctor or pharmacist for further guidance.


Common side-effects are

  1. Skin rash
  2. Blisters
  3. Hives
  4. Itching
  5. Burning
  6. Vaginal discharge
  7. Peeling
  8. Redness
  9. Swelling
  10. Stinging
  11. Edema
  12. Erythema
  13. Pain
  14. Cramping
  15. Bleeding
  16. Vulvar lesion
  17. Dizziness
  18. Trouble breathing
  19. Nausea
  20. Vomiting
  21. Abnormal liver function test
  22. Polyuria
  23. Soreness

Precautions and Warning

Patient should give full personal and family history to the doctor. If the patient has any allergic reactions please mention it to the doctor.

If the infection does not start to abade then that means you have infection other than the yeast. Please consult your doctor and stop using the medication. If you doubt that you may have HIV infection because of recurrent vaginal infections then please consult your doctor and have the tests recommended.

Pregnancy and Breast-Feeding

The research has been done on animals intravaginally and even after high doses it does not show any teratogenicity. But high doses orally have been harmful and toxic. The research on humans suggested that women in their second and third trimester, treatment of vaginal candidiasis by clotrimazole is not associated with any harmful effects on the fetus but during first trimester it does associate with fetal harm.

It has been not known if it excretes into breast milk or not, please consult your doctor before using.

Drug and Interaction

Some drugs like antibiotics, corticosteroids like prednisone and drugs like methotrexate, cyclosporine that suppresses the immune system should not be taken with antifungal drugs like Gyne-Lotrimin. Please consult your physician before using.

Some frequently asked questions about Clotrimazole

What is clotrimazole?

Clotrimazole is an antifungal medication used to treat various fungal infections. It belongs to the class of drugs known as azoles and works by stopping the growth of fungi.

What conditions can clotrimazole treat?

Clotrimazole can be used to treat a range of fungal infections, including athlete's foot, jock itch, ringworm, vaginal yeast infections, and oral thrush. It is important to use clotrimazole specifically for the condition it is intended to treat.

How does clotrimazole work?

Clotrimazole works by inhibiting the growth of fungi. It disrupts the cell membranes of the fungi, leading to the leakage of essential components and ultimately causing the death of the fungi.

Is clotrimazole safe to use?

Clotrimazole is generally considered safe when used as directed. However, like any medication, it may have some side effects. Common side effects include itching, burning, irritation, or redness at the application site. If you experience any severe or persistent side effects, it is important to consult a healthcare professional.

Can clotrimazole be used during pregnancy or breastfeeding?

It is advisable to consult a healthcare professional before using clotrimazole during pregnancy or while breastfeeding. They can evaluate the potential risks and benefits and provide guidance based on your specific situation.

How should clotrimazole be applied?

Clotrimazole is available in various forms, such as creams, powders, sprays, and lozenges, depending on the intended use. Follow the instructions provided by your healthcare professional or the product packaging for the appropriate application method and dosage.

How long does it take for clotrimazole to work?

The time it takes for clotrimazole to work can vary depending on the type and severity of the fungal infection. In general, improvement in symptoms can be seen within a few days of starting treatment. However, it is important to complete the full course of treatment as prescribed, even if symptoms improve earlier.

Can clotrimazole interact with other medications?

Clotrimazole may interact with certain medications, including oral anticoagulants (blood thinners) and some anticonvulsant drugs. Inform your healthcare professional about all the medications, supplements, or herbal products you are taking to avoid any potential interactions.

Can clotrimazole be used for children?

Clotrimazole can be used for children, but the specific usage and dosage should be determined by a healthcare professional based on the child's age, weight, and the type of fungal infection.

What should I do if my symptoms do not improve or worsen?

If your symptoms do not improve or worsen despite using clotrimazole as directed, it is recommended to consult a healthcare professional for further evaluation and guidance. They can assess your condition and recommend appropriate treatment options.

Brand names

Brand names in US

Femcare, Fungoid, Lotrimin, Lotrimin AF, Mycelex, Mycelex-7, Mycelex-G, Prescription Strength Desenex.

Brand names in Mexico

Altenal, Candimon, Candiphen, Canesten, Cinabel, Clocan, Clomacin, Dermasten, Euroderm, Liferzol, Lomecan V, Lonestin, Lotrimin, Rangyn, Tenescan, Toczol, Traxelan.

Brand names in Europe

Antimicotico, Gyno-Canesten, Trimysten, Canesten, Fungidermo, Gine Canesten, Ictan, Micomisan, Micoter, Abtrim, Athletes Foot Cream, Candiden, Canesten, Canesten Combi, Fungederm, Masnoderm, Medisport Athlete's Foot, Mycil Gold, Privacom.

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