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Antifungal drug Gyne-Lotrimin (clotrimazole)

It is the brand name for Clotrimazole. It is an antifungal medicine that is used to treat vaginal yeast infections. This product comes in two form tablet or cream. Cream is used to apply on the outer region of the vagina.

Mechanism Of action (MOA)

Clotrimazole is an anti funfal medicine which kills the fungal cells by inhibiting the permeability of the fungal cell wall. The cell membrane is formed by sterols and ergosterol therefore it binds with phospholipids and blocks the production of ergosterol and sterol. This causes cell death.

Uses of Gyne-Lotrimin

This drug is mainly used for treating vaginal yeast infections. This medicine comes in cream and tablet form. It works by inhibiting the growth of yeast and stops the itching and burning. Apply cream on the outside skin of the vagina.

Dosage and Administration

As the medicine we are taking about is in cream form, we will apply the cream with an applicator at bed time. The applicator should be disposed after using and a new applicator should be used for 7 days. The itching on the vulva can be treated by applying cream on the outer lips of vulva where itching occurs. This cream is only for yeast infections and not for others. It is available in 100mg and 200mg vaginal suppository that can be applied at bed time.

Side-Effects of Gyne-Lotrimin

Common side-effects are

1) Skin rash

2) Blisters

3) Hives

4) Itching

5) Burning

6) Vaginal discharge

7) Peeling

8) Redness

9) Swelling

10) Stinging

11) Edema

12) Erythema

13) Pain

14) Cramping

15) Bleeding

16) Vulvar lesion

17) Dizziness

18) Trouble breathing

19) Nausea

20) Vomiting

21) Abnormal liver function test

22) Polyuria

23) Soreness

Precautions and Warning

Patient should give full personal and family history to the doctor. If the patient has any allergic reactions please mention it to the doctor.

If the infection does not start to abade then that means you have infection other than the yeast. Please consult your doctor and stop using the medication. If you doubt that you may have HIV infection because of recurrent vaginal infections then please consult your doctor and have the tests recommended.

Pregnancy and Breast-Feeding

The research has been done on animals intravaginally and even after high doses it does not show any teratogenicity. But high doses orally have been harmful and toxic. The research on humans suggested that women in their second and third trimester, treatment of vaginal candidiasis by clotrimazole is not associated with any harmful effects on the fetus but during first trimester it does associate with fetal harm.

It has been not known if it excretes into breast milk or not, please consult your doctor before using.

Drug and Interaction

Some drugs like antibiotics, corticosteroids like prednisone and drugs like methotrexate, cyclosporine that suppresses the immune system should not be taken with antifungal drugs like Gyne-Lotrimin. Please consult your physician before using.

Brand names in US

Femcare, Fungoid, Lotrimin, Lotrimin AF, Mycelex, Mycelex-7, Mycelex-G, Prescription Strength Desenex.

Brand names in Mexico

Altenal, Candimon, Candiphen, Canesten, Cinabel, Clocan, Clomacin, Dermasten, Euroderm, Liferzol, Lomecan V, Lonestin, Lotrimin, Rangyn, Tenescan, Toczol, Traxelan.

Brand names in Europe

Antimicotico, Gyno-Canesten, Trimysten, Canesten, Fungidermo, Gine Canesten, Ictan, Micomisan, Micoter, Abtrim, Athletes Foot Cream, Candiden, Canesten, Canesten Combi, Fungederm, Masnoderm, Medisport Athlete's Foot, Mycil Gold, Privacom.

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